{"product_id":"ly2109761-s2704","title":"LY2109761","description":"\u003cp\u003e\u003cstrong\u003eLY2109761\u003c\/strong\u003e is an inhibitor of TGF-beta \/ Smad used in studies of TGF-beta \/ Smad Signaling and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure Smad-mediated transcription, differentiation, and fibrotic signaling and caspase-associated cell-death signaling and survival decisions in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting TGF-beta \/ Smad, LY2109761 can be used to examine Smad-mediated transcription, differentiation, and fibrotic signaling and caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TGF-beta \/ Smad\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to TGF-beta \/ Smad Signaling and Apoptosis and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, LY2109761 is appropriate when a defined chemical perturbant is needed to connect TGF-beta \/ Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805703676249,"sku":"S2704-5MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805703709017,"sku":"S2704-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805703741785,"sku":"S2704-200MG","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805703774553,"sku":"S2704-1G","price":4904.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805703807321,"sku":"S2704-1ML\/DMSO","price":390.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/LY2109761-chemical-structure-s2704.gif?v=1776175559","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ly2109761-s2704","provider":"Absource Diagnostics","version":"1.0","type":"link"}