{"product_id":"lrrk2-antibody-sc-f1550","title":"LRRK2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eLRRK2 (Leucine-rich repeat kinase 2) is a highly complex protein featuring four protein-protein interaction domains and two distinct enzymatic activities. As a serine-threonine kinase, LRRK2 can autophosphorylate its own residues and phosphorylate a select group of external substrates. Structurally, LRRK2 includes N-terminal leucine-rich repeats (LRR), a Ras-like GTPase (ROC) domain, an MLK protein kinase domain, and a C-terminal WD40 repeat domain.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasmic vesicle, golgi apparatus, cell projection, and endoplasmic reticulum (pmid:2, which can matter when signal is compared across treatments or changing cell states. Following LRRK2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eLRRK2 is commonly interpreted in the context of neuroscience and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasmic vesicle, golgi apparatus, and cell projection, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasmic vesicle, golgi apparatus, and cell projection across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LRRK2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LRRK2 reflect biology rather than handling. When interpreting LRRK2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep LRRK2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577773728089,"sku":"F1550-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577773760857,"sku":"F1550-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577773793625,"sku":"F1550-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1550-wb.gif?v=1773599863","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/lrrk2-antibody-sc-f1550","provider":"Absource Diagnostics","version":"1.0","type":"link"}