{"product_id":"leucovorin-calcium-pentahydrate-folinic-acid-s1236","title":"Leucovorin Calcium Pentahydrate (Folinic acid)","description":"\u003cp\u003e\u003cstrong\u003eLeucovorin Calcium Pentahydrate (Folinic acid)\u003c\/strong\u003e is an inhibitor of DHFR used in studies of DNA Damage Response. It is especially relevant in cancer, dna damage \/ repair, and metabolism models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DHFR, Leucovorin Calcium Pentahydrate (Folinic acid) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage \/ repair, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DHFR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Leucovorin Calcium Pentahydrate (Folinic acid) is appropriate when a defined chemical perturbant is needed to connect DHFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage \/ repair, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"50 mg","offer_id":57805253280089,"sku":"S1236-50MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":57805253312857,"sku":"S1236-250MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805253345625,"sku":"S1236-1G","price":560.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Leucovorin-Calcium-chemical-structure-S1236.gif?v=1776173192","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/leucovorin-calcium-pentahydrate-folinic-acid-s1236","provider":"Absource Diagnostics","version":"1.0","type":"link"}