{"product_id":"ku-55933-s1092","title":"KU-55933","description":"\u003cp\u003e\u003cstrong\u003eKU-55933\u003c\/strong\u003e is an inhibitor of ATM and ATR used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. It is especially relevant in autophagy, cancer, and cell signaling models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ATM and ATR, KU-55933 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ATM and ATR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KU-55933 is appropriate when a defined chemical perturbant is needed to connect ATM and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805218709849,"sku":"S1092-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805218742617,"sku":"S1092-10MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805218775385,"sku":"S1092-50MG","price":685.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805218808153,"sku":"S1092-200MG","price":1248.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805218840921,"sku":"S1092-1G","price":2742.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805218873689,"sku":"S1092-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/KU-55933-chemical-structure-S1092.gif?v=1776172885","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ku-55933-s1092","provider":"Absource Diagnostics","version":"1.0","type":"link"}