{"product_id":"ku-0060648-s8045","title":"KU-0060648","description":"\u003cp\u003e\u003cstrong\u003eKU-0060648\u003c\/strong\u003e is an inhibitor of DNA-PK and PI3K beta and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DNA-PK and PI3K beta and related targets, KU-0060648 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DNA-PK and PI3K beta and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KU-0060648 is appropriate when a defined chemical perturbant is needed to connect DNA-PK and PI3K beta and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57809573708121,"sku":"S8045-2MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809573740889,"sku":"S8045-25MG","price":855.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809573773657,"sku":"S8045-100MG","price":1641.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809573806425,"sku":"S8045-1G","price":4884.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/KUOO60648-chemical-structure-s8045.gif?v=1776202252","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ku-0060648-s8045","provider":"Absource Diagnostics","version":"1.0","type":"link"}