{"product_id":"kt-474-sar444656-e1655","title":"KT-474 (SAR444656)","description":"\u003cp\u003e\u003cstrong\u003eKT-474 (SAR444656)\u003c\/strong\u003e is a modulator of TLR and Interleukins used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant in immunology and inflammation models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating TLR and Interleukins, KT-474 (SAR444656) can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TLR and Interleukins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KT-474 (SAR444656) is appropriate when a defined chemical perturbant is needed to connect TLR and Interleukins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57804428018009,"sku":"E1655-1MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57804428050777,"sku":"E1655-5MG","price":341.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804428083545,"sku":"E1655-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804428116313,"sku":"E1655-100MG","price":1739.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e1655-KT-474-chemical-structure.png?v=1776167113","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/kt-474-sar444656-e1655","provider":"Absource Diagnostics","version":"1.0","type":"link"}