{"product_id":"ksq-4279-usp1-in-1-e1214","title":"KSQ-4279 (USP1-IN-1)","description":"\u003cp\u003e\u003cstrong\u003eKSQ-4279 (USP1-IN-1)\u003c\/strong\u003e is an inhibitor of E3 Ligase and Proteasome used in studies of DNA Damage Response and Protein Degradation \/ Proteasome. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in cancer, dna damage \/ repair, and protein homeostasis models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting E3 Ligase and Proteasome, KSQ-4279 (USP1-IN-1) can be used to examine checkpoint activation, DNA repair, and genome-stability control and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage \/ repair, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving E3 Ligase and Proteasome\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KSQ-4279 (USP1-IN-1) is appropriate when a defined chemical perturbant is needed to connect E3 Ligase and Proteasome with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage \/ repair, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804358254937,"sku":"E1214-5MG","price":470.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804358287705,"sku":"E1214-25MG","price":1412.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804358320473,"sku":"E1214-100MG","price":3528.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e1214-KSQ-4279-chemical-structure.png?v=1776166672","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ksq-4279-usp1-in-1-e1214","provider":"Absource Diagnostics","version":"1.0","type":"link"}