{"product_id":"krit1-antibody-sc-f3414","title":"KRIT1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eKRIT1 (Krev interaction trapped 1), also known as CCM1, is a scaffolding protein crucial for endothelial cell function, particularly in maintaining blood-brain barrier integrity and regulating vascular morphogenesis. KRIT1 features an N-terminal Nudix domain, three NPxY\/F motifs, four ankyrin repeats (forming an ankyrin repeat domain or ARD), and a C-terminal FERM domain subdivided into F1, F2, and F3 lobes. Depending on the literature source, KRIT1 may also be discussed as CCM1 and Krev interaction trapped protein 1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes celljunction, cellmembrane, cytoplasm, and cytoskeleton, which can matter when signal is compared across treatments or changing cell states. Following KRIT1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eKRIT1 is commonly interpreted in the context of inflammation, cardiovascular, and oxidative stress research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans celljunction, cellmembrane, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between celljunction, cellmembrane, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003eredox-associated shifts that may alter abundance, localization, or pathway coupling\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for KRIT1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in KRIT1 reflect biology rather than handling. When interpreting KRIT1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep KRIT1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578021486937,"sku":"F3414-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578021519705,"sku":"F3414-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578021552473,"sku":"F3414-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3414-IF.png?v=1773601197","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/krit1-antibody-sc-f3414","provider":"Absource Diagnostics","version":"1.0","type":"link"}