{"product_id":"ko-947-s8569","title":"KO-947","description":"\u003cp\u003e\u003cstrong\u003eKO-947\u003c\/strong\u003e is an inhibitor of ERK and ERK1 used in studies of MAPK \/ ERK Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ERK and ERK1, KO-947 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ERK and ERK1\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KO-947 is appropriate when a defined chemical perturbant is needed to connect ERK and ERK1 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809622139225,"sku":"S8569-5MG","price":252.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809622171993,"sku":"S8569-25MG","price":756.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/ko-947-chemical-structure-s8569.gif?v=1776202974","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ko-947-s8569","provider":"Absource Diagnostics","version":"1.0","type":"link"}