{"product_id":"knk437-s7750","title":"KNK437","description":"\u003cp\u003e\u003cstrong\u003eKNK437\u003c\/strong\u003e is an inhibitor of HSP90 used in studies of target-focused biology. It is especially relevant in cancer, cell cycle, and protein homeostasis models, where defined compound exposure can be linked to annotated target biology and downstream cellular responses.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HSP90, KNK437 can be used to examine annotated target biology and downstream cellular responses. That positioning is consistent with concentration-response inhibition and target-dependence studies and with follow-up studies that compare concentration-dependent responses across orthogonal assay formats. In cancer, cell cycle, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HSP90\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer, cell cycle, and protein homeostasis models\u003c\/li\u003e\n\u003cli\u003eCombination studies with orthogonal perturbagens\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KNK437 is appropriate when a defined chemical perturbant is needed to connect HSP90 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809537597785,"sku":"S7750-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57809537630553,"sku":"S7750-200MG","price":979.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809537663321,"sku":"S7750-1G","price":1955.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/knk437-chemical-structure-s7750.gif?v=1776201805","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/knk437-s7750","provider":"Absource Diagnostics","version":"1.0","type":"link"}