{"product_id":"jte-013-s7182","title":"JTE 013","description":"\u003cp\u003e\u003cstrong\u003eJTE 013\u003c\/strong\u003e is an antagonist of S1P Receptors used in studies of GPCR Signaling. It is especially relevant in immunology and inflammation models, where defined compound exposure can be linked to receptor-driven second-messenger signaling and desensitization dynamics.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking S1P Receptors, JTE 013 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving S1P Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, JTE 013 is appropriate when a defined chemical perturbant is needed to connect S1P Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809462198617,"sku":"S7182-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809462231385,"sku":"S7182-50MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809462264153,"sku":"S7182-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/JTE-013-chemical-structure-s7182.gif?v=1776201050","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/jte-013-s7182","provider":"Absource Diagnostics","version":"1.0","type":"link"}