{"product_id":"jms-17-2-s0135","title":"JMS-17-2","description":"\u003cp\u003e\u003cstrong\u003eJMS-17-2\u003c\/strong\u003e is an antagonist of GPR used in studies of GPCR Signaling. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics in cell signaling models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking GPR, JMS-17-2 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving GPR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, JMS-17-2 is appropriate when a defined chemical perturbant is needed to connect GPR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805081313625,"sku":"S0135-5MG","price":173.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805081346393,"sku":"S0135-25MG","price":519.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805081379161,"sku":"S0135-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805081411929,"sku":"S0135-1G","price":3921.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s0135-jms-17-2-chemical-structure.gif?v=1776171884","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/jms-17-2-s0135","provider":"Absource Diagnostics","version":"1.0","type":"link"}