{"product_id":"ivacaftor-vx-770-s1144","title":"Ivacaftor (VX-770)","description":"\u003cp\u003e\u003cstrong\u003eIvacaftor (VX-770)\u003c\/strong\u003e is an activator of CFTR used in studies of ion-channel pharmacology. In practice, this places the compound in experiments that measure ion conductance, membrane potential, and electrophysiological responses in cell signaling and endocrinology models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating CFTR, Ivacaftor (VX-770) can be used to examine ion conductance, membrane potential, and electrophysiological responses. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CFTR\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003eElectrophysiology, ion-flux, and membrane-potential studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cell signaling and endocrinology models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Ivacaftor (VX-770) is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805230571865,"sku":"S1144-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805230604633,"sku":"S1144-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805230637401,"sku":"S1144-200MG","price":1366.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805230670169,"sku":"S1144-1G","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805230702937,"sku":"S1144-1ML\/DMSO","price":232.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/VX-770-chemical-structure-S1144.gif?v=1776172981","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ivacaftor-vx-770-s1144","provider":"Absource Diagnostics","version":"1.0","type":"link"}