{"product_id":"irinotecan-cpt-11-s1198","title":"Irinotecan (CPT-11)","description":"\u003cp\u003e\u003cstrong\u003eIrinotecan (CPT-11)\u003c\/strong\u003e is an inhibitor of Topoisomerase used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Topoisomerase, Irinotecan (CPT-11) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Topoisomerase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Irinotecan (CPT-11) is appropriate when a defined chemical perturbant is needed to connect Topoisomerase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"100 mg","offer_id":57805242597721,"sku":"S1198-100MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805242630489,"sku":"S1198-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805242663257,"sku":"S1198-1ML\/DMSO","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Irinotecan-chemical-structure-S1198.gif?v=1776173096","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/irinotecan-cpt-11-s1198","provider":"Absource Diagnostics","version":"1.0","type":"link"}