{"product_id":"ip3-receptor-antibody-sc-f1383","title":"Phospho-IP3 Receptor (Ser1756) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eIP3 Receptor is a target of interest in many antibody-based workflows. Inositol 1,4,5-triphosphate receptor (IP3R) is an intracellular calcium release channel located in the endoplasmic reticulum, essential for Ca2+ release from intracellular stores. There are three types (IP3R1, 2, and 3), activated by inositol 1,4,5-triphosphate (IP3). IP3R is phosphorylated by cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and Ca2+\/calmodulin-dependent protein kinase II (CaMKII). Depending on the literature source, IP3 Receptor may also be discussed as Phospho-IP3 Receptor (Ser1756) and Phospho IP3R (Ser 1756).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, and membrane, which can matter when signal is compared across treatments or changing cell states. Following IP3 Receptor across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eIP3 Receptor is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for IP3 Receptor. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in IP3 Receptor reflect biology rather than handling. When interpreting IP3 Receptor, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep IP3 Receptor trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577716416857,"sku":"F1383-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577716449625,"sku":"F1383-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577716482393,"sku":"F1383-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1383-wb.gif?v=1773599675","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ip3-receptor-antibody-sc-f1383","provider":"Absource Diagnostics","version":"1.0","type":"link"}