{"product_id":"incb3344-s8220","title":"INCB3344","description":"\u003cp\u003e\u003cstrong\u003eINCB3344\u003c\/strong\u003e is an antagonist of CCR used in studies of Immune Signaling and GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-mediated signaling and inflammatory effector responses and receptor-driven second-messenger signaling and desensitization dynamics in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking CCR, INCB3344 can be used to examine cytokine-mediated signaling and inflammatory effector responses and receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CCR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Immune Signaling and GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, INCB3344 is appropriate when a defined chemical perturbant is needed to connect CCR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809589535065,"sku":"S8220-5MG","price":213.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809589567833,"sku":"S8220-25MG","price":637.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809589600601,"sku":"S8220-100MG","price":1591.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809589633369,"sku":"S8220-1ML\/DMSO","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s8220-incb3344-chemical-structure.gif?v=1776202460","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/incb3344-s8220","provider":"Absource Diagnostics","version":"1.0","type":"link"}