{"product_id":"idh1-antibody-sc-f0576","title":"IDH1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eIDH1, a member of the β-decarboxydehydrogenase family, is found in the cytoplasm and peroxisomes. It catalyzes the conversion of isocitrate to α-KG, CO2, and NADPH, essential for various cellular processes including antioxidant defense, dioxygenase activity, lipid synthesis, and glucose metabolism. Mutations in IDH1 active sites impair its function, affecting cellular detoxification and metabolic processes.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and peroxisome, which can matter when signal is compared across treatments or changing cell states. Following IDH1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eIDH1 is commonly interpreted in the context of cancer and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and peroxisome, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and peroxisome across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for IDH1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in IDH1 reflect biology rather than handling. When interpreting IDH1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep IDH1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577472524633,"sku":"F0576-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577472557401,"sku":"F0576-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577472590169,"sku":"F0576-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0576-IF.png?v=1773598646","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/idh1-antibody-sc-f0576","provider":"Absource Diagnostics","version":"1.0","type":"link"}