{"product_id":"icrt3-s8647","title":"iCRT3","description":"\u003cp\u003e\u003cstrong\u003eiCRT3\u003c\/strong\u003e is an antagonist of Wnt \/ beta-catenin used in studies of Wnt Signaling. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling in cancer, cell signaling, and developmental biology models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking Wnt \/ beta-catenin, iCRT3 can be used to examine beta-catenin-dependent transcription and developmental signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Wnt \/ beta-catenin\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Wnt Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, iCRT3 is appropriate when a defined chemical perturbant is needed to connect Wnt \/ beta-catenin with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809630560601,"sku":"S8647-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809630593369,"sku":"S8647-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809630626137,"sku":"S8647-100MG","price":901.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809630658905,"sku":"S8647-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/icrt3-chemical-structure-s8647.gif?v=1776203675","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/icrt3-s8647","provider":"Absource Diagnostics","version":"1.0","type":"link"}