{"product_id":"icenticaftor-qbw251-s9972","title":"Icenticaftor (QBW251)","description":"\u003cp\u003e\u003cstrong\u003eIcenticaftor (QBW251)\u003c\/strong\u003e is a research compound associated with CFTR and is relevant to studies of ion-channel pharmacology. It is especially relevant in cell signaling and endocrinology models, where defined compound exposure can be linked to ion conductance, membrane potential, and electrophysiological responses.\u003c\/p\u003e\n\n\u003cp\u003eThe current annotation links Icenticaftor (QBW251) to CFTR, supporting target-focused studies that measure ion conductance, membrane potential, and electrophysiological responses without assigning a more specific primary mechanism than the dataset provides. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CFTR\u003c\/li\u003e\n\u003cli\u003eElectrophysiology, ion-flux, and membrane-potential studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cell signaling and endocrinology models\u003c\/li\u003e\n\u003cli\u003eCombination studies with orthogonal perturbagens\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Icenticaftor (QBW251) is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57809763434841,"sku":"S9972-1MG","price":451.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809763467609,"sku":"S9972-5MG","price":1355.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809763500377,"sku":"S9972-25MG","price":4065.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s9972-icenticaftor-chemical-structure.gif?v=1776205280","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/icenticaftor-qbw251-s9972","provider":"Absource Diagnostics","version":"1.0","type":"link"}