{"product_id":"histone-h4-antibody-sc-f1267","title":"Histone H4 (tri methyl Lys20) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTri-Methyl-Histone H4 (Lys20), also known as H4K20me3, is a specific histone post-translational modification crucial for maintaining genomic integrity and regulating chromatin structure. Histone H4 lysine 20 methylation exists in three states: mono-methylation (H4K20me1), di-methylation (H4K20me2), and tri-methylation (H4K20me3), with H4K20me3 being the trimethylation mark on the lysine 20 residue of histone H4. Depending on the literature source, Histone H4 may also be discussed as Histone H4 (tri methyl Lys20) and Histone H4 (tri methyl K20).\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, nucleosome core, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following Histone H4 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eHistone H4 is commonly interpreted in the context of dna damage \/ repair and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, nucleosome core, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, nucleosome core, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Histone H4. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Histone H4 reflect biology rather than handling. When interpreting Histone H4, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep Histone H4 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577675096409,"sku":"F1267-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577675129177,"sku":"F1267-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577675161945,"sku":"F1267-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1267-wb.gif?v=1773599517","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/histone-h4-antibody-sc-f1267","provider":"Absource Diagnostics","version":"1.0","type":"link"}