{"product_id":"histone-h3-antibody-sc-f0246","title":"Phospho-Histone H3 (Ser10) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePhospho-Histone H3 (Ser 10) is a dynamic post-translational modification by phosphorylation at the 10th serine residue on the N-terminal tail of histone H3, involved in chromosome condensation during mitosis and transcriptional activation of immediate-early (IE) genes in response to growth factors, stress, and oncogenic signals. Structurally, it occurs on the amino-terminal tail of histone H3, neutralizing positive charges and weakening histone-DNA interactions to promote chromatin remodeling. Depending on the literature source, Histone H3 may also be discussed as Phospho-Histone H3 (Ser10) and Histone H3 (phospho S10).\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, nucleosome core, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following Histone H3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eHistone H3 is commonly interpreted in the context of cancer, neuroscience, and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, nucleosome core, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, nucleosome core, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Histone H3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Histone H3 reflect biology rather than handling. When interpreting Histone H3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep Histone H3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577434841433,"sku":"F0246-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577434874201,"sku":"F0246-100UL","price":419.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577434906969,"sku":"F0246-2X100UL","price":629.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0246-IF.png?v=1773598244","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/histone-h3-antibody-sc-f0246","provider":"Absource Diagnostics","version":"1.0","type":"link"}