{"product_id":"gsk429286a-s1474","title":"GSK429286A","description":"\u003cp\u003e\u003cstrong\u003eGSK429286A\u003c\/strong\u003e is an inhibitor of ROCK used in studies of kinase signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to phosphorylation signaling, target engagement, and selectivity relationships in cancer, cardiovascular, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ROCK, GSK429286A can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ROCK\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer, cardiovascular, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GSK429286A is appropriate when a defined chemical perturbant is needed to connect ROCK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57805293224281,"sku":"S1474-2MG","price":176.0,"currency_code":"EUR","in_stock":true},{"title":"20 mg","offer_id":57805293257049,"sku":"S1474-20MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805293289817,"sku":"S1474-50MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805293322585,"sku":"S1474-1G","price":4904.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805293355353,"sku":"S1474-1ML\/DMSO","price":363.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/GSK429286A-chemical-structure-S1474.gif?v=1776173595","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/gsk429286a-s1474","provider":"Absource Diagnostics","version":"1.0","type":"link"}