{"product_id":"gsk180736a-gsk180736-s8489","title":"GSK180736A (GSK180736)","description":"\u003cp\u003e\u003cstrong\u003eGSK180736A (GSK180736)\u003c\/strong\u003e is an inhibitor of ROCK used in studies of GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to receptor-driven second-messenger signaling and desensitization dynamics in cancer, cardiovascular, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ROCK, GSK180736A (GSK180736) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cardiovascular, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ROCK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GSK180736A (GSK180736) is appropriate when a defined chemical perturbant is needed to connect ROCK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809613979993,"sku":"S8489-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809614012761,"sku":"S8489-50MG","price":439.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/gsk180736a-chemical-structure-S8489.gif?v=1776202759","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/gsk180736a-gsk180736-s8489","provider":"Absource Diagnostics","version":"1.0","type":"link"}