{"product_id":"grp60-antibody-sc-f3350","title":"Calreticulin Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eGRP60 is a target of interest in many antibody-based workflows. Calreticulin (D16K15) is a multifunctional calcium-binding chaperone primarily residing in the endoplasmic reticulum (ER), where it regulates calcium homeostasis and ensures proper protein folding and quality control. Structurally, it consists of three main domains: an N-terminal lectin-like domain for glycoprotein binding, a proline-rich P-domain involved in chaperone activity, and a negatively charged C-terminal domain responsible for calcium storage. Depending on the literature source, GRP60 may also be discussed as Calreticulin and CRP55.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, and extracellular matrix, which can matter when signal is compared across treatments or changing cell states. Following GRP60 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eGRP60 is commonly interpreted in the context of immunology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for GRP60. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in GRP60 reflect biology rather than handling. When interpreting GRP60, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep GRP60 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578016735577,"sku":"F3350-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578016768345,"sku":"F3350-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578016801113,"sku":"F3350-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3350-IF.png?v=1773601138","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/grp60-antibody-sc-f3350","provider":"Absource Diagnostics","version":"1.0","type":"link"}