{"product_id":"gne-7883-e1563","title":"GNE-7883","description":"\u003cp\u003e\u003cstrong\u003eGNE-7883\u003c\/strong\u003e is an inhibitor of KRAS used in studies of MAPK \/ ERK Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer, cell signaling, and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting KRAS, GNE-7883 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. This context is compatible with phosphorylation mapping, pathway-response, and growth assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In cancer, cell signaling, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving KRAS\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer, cell signaling, and metabolism models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GNE-7883 is appropriate when a defined chemical perturbant is needed to connect KRAS with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57804412453209,"sku":"E1563-1MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57804412485977,"sku":"E1563-5MG","price":341.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804412518745,"sku":"E1563-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804412551513,"sku":"E1563-100MG","price":1739.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E1563-GNE-7883-chemical-structure.png?v=1776167006","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/gne-7883-e1563","provider":"Absource Diagnostics","version":"1.0","type":"link"}