{"product_id":"gne-781-s8665","title":"GNE-781","description":"\u003cp\u003e\u003cstrong\u003eGNE-781\u003c\/strong\u003e is an inhibitor of BET used in studies of Epigenetic Regulation. In practice, this places the compound in experiments that measure chromatin-state control, histone modification, and transcriptional regulation in cancer and epigenetics models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting BET, GNE-781 can be used to examine chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving BET\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GNE-781 is appropriate when a defined chemical perturbant is needed to connect BET with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809632526681,"sku":"S8665-5MG","price":421.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809632559449,"sku":"S8665-25MG","price":1264.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809632592217,"sku":"S8665-100MG","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809632624985,"sku":"S8665-1ML\/DMSO","price":560.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s8665-gne-781-chemical-structure.gif?v=1776204005","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/gne-781-s8665","provider":"Absource Diagnostics","version":"1.0","type":"link"}