{"product_id":"fmrp-antibody-sc-f1373","title":"FMRP Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eFMRP (Fragile X Mental Retardation Protein) is an RNA-binding protein encoded by the FMR1 gene, primarily expressed in the brain. It functions as a master regulator of activity-dependent neurodevelopment, with null mutants manifesting hyperexcitability and reduced activity-dependent modulation of synapse maturation, refinement and plasticity. FMRP functions as a translational repressor of specific mRNAs and plays a role in mRNA editing, pre-mRNA splicing, and the microRNA pathway. Depending on the literature source, FMRP may also be discussed as Fragile X Mental Retardation Protein.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, centromere, and chromosome, which can matter when signal is compared across treatments or changing cell states. Following FMRP across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eFMRP is commonly interpreted in the context of neuroscience and dna damage \/ repair research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and centromere, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and centromere across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for FMRP. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in FMRP reflect biology rather than handling. When interpreting FMRP, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep FMRP trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577710616921,"sku":"F1373-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577710649689,"sku":"F1373-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577710682457,"sku":"F1373-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1373-IF.png?v=1773599661","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/fmrp-antibody-sc-f1373","provider":"Absource Diagnostics","version":"1.0","type":"link"}