{"product_id":"fasudil-ha-1077-hydrochloride-s1573","title":"Fasudil (HA-1077)Hydrochloride","description":"\u003cp\u003e\u003cstrong\u003eFasudil (HA-1077)Hydrochloride\u003c\/strong\u003e is an inhibitor of ROCK and PKA and related targets used in studies of MAPK \/ ERK Signaling and Calcium Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and calcium flux, excitability, and secretion-linked signaling in cancer, cardiovascular, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ROCK and PKA and related targets, Fasudil (HA-1077)Hydrochloride can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and calcium flux, excitability, and secretion-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ROCK and PKA and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and Calcium Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Fasudil (HA-1077)Hydrochloride is appropriate when a defined chemical perturbant is needed to connect ROCK and PKA and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"200 mg","offer_id":57805314392409,"sku":"S1573-200MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":57805314425177,"sku":"S1573-500MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805314457945,"sku":"S1573-1G","price":390.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805314490713,"sku":"S1573-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Fasudil-HA-1077-chemical-structure-S1573.gif?v=1776173750","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/fasudil-ha-1077-hydrochloride-s1573","provider":"Absource Diagnostics","version":"1.0","type":"link"}