{"product_id":"esr1-antibody-sc-f1063","title":"Estrogen Receptor α Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eESR1 is a target of interest in many antibody-based workflows. Estrogen receptor α (ERα) is a ligand-dependent transcription factor and part of the nuclear hormone receptor (NHR) superfamily. It has a globular ligand-binding domain (LBD) that facilitates hormone binding, dimerization, and interaction with coregulators. The human ERα gene is located on chromosome 6, and the full-length protein consists of 595 amino acids with a molecular size of 66 kDa. Depending on the literature source, ESR1 may also be discussed as Estrogen Receptor alpha.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, golgi apparatus, and membrane, which can matter when signal is compared across treatments or changing cell states. Following ESR1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eESR1 is commonly interpreted in the context of cancer, cardiovascular, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and golgi apparatus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and golgi apparatus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ESR1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ESR1 reflect biology rather than handling. When interpreting ESR1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ESR1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577601630553,"sku":"F1063-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577601663321,"sku":"F1063-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577601696089,"sku":"F1063-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1063-IF.png?v=1773599236","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/esr1-antibody-sc-f1063","provider":"Absource Diagnostics","version":"1.0","type":"link"}