{"product_id":"esi-09-s7499","title":"ESI-09","description":"\u003cp\u003e\u003cstrong\u003eESI-09\u003c\/strong\u003e is an inhibitor of PKA used in studies of GPCR Signaling. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics in cancer and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PKA, ESI-09 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PKA\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, ESI-09 is appropriate when a defined chemical perturbant is needed to connect PKA with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809490444633,"sku":"S7499-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809490477401,"sku":"S7499-100MG","price":776.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809490510169,"sku":"S7499-1G","price":1936.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/esi-09-chemical-structure-s7499.gif?v=1776201472","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/esi-09-s7499","provider":"Absource Diagnostics","version":"1.0","type":"link"}