{"product_id":"ercc8-antibody-sc-f3160","title":"ERCC8 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eERCC8 (Cockayne Syndrome A, CSA) is an excision repair cross-complementation gene (ERCC), a WD-repeat protein coded for Cockayne syndrome A or CSA protein, involved in transcription-coupled nucleotide excision repair (TC-NER), a critical DNA damage repair pathway that removes UV-induced lesions such as 6-4 photoproducts and cyclobutane pyrimidine dimers. Structurally, ERCC8 contains multiple WD40 domains that facilitate protein-protein interactions and functions as part of the CSA ubiquitin ligase complex (DDB1-CUL4-X-box E3 ligase), regulating the degradation of ERCC6 (CSB) after DNA damage.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following ERCC8 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eERCC8 is commonly interpreted in the context of dna damage \/ repair research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ERCC8. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ERCC8 reflect biology rather than handling. When interpreting ERCC8, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ERCC8 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578005332313,"sku":"F3160-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578005365081,"sku":"F3160-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578005397849,"sku":"F3160-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3160-wb.gif?v=1773600971","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ercc8-antibody-sc-f3160","provider":"Absource Diagnostics","version":"1.0","type":"link"}