{"product_id":"eif4g2-p97-antibody-sc-f1432","title":"eIF4G2\/p97 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eeIF4G2\/p97 is a target of interest in many antibody-based workflows. eIF4G2, also known as p97, NAT1, and DAP5, is a member of the eIF4G protein family, which includes the major isoform eIF4GI (EIF4G1), the least-expressed isoform eIF4GII (EIF4G3), and eIF4G2 (EIF4G2). eIF4G2 is a 97-kDa protein homologous to the C-terminal two-thirds of eIF4GI, produced by picornaviral proteolysis. It is a novel target for mRNA editing by Apobec-1, which has RNA-binding and cytidine deaminase activities. eIF4G2 plays a crucial role in apoptosis, cell survival, differentiation, and embryonic development by activating the translation of key proteins. Depending on the literature source, eIF4G2\/p97 may also be discussed as eIF4G2\/p97.\u003c\/p\u003e\u003cp\u003eReported cellular context includes adherens junction, axon, and cytosol, which can matter when signal is compared across treatments or changing cell states. Following eIF4G2\/p97 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eeIF4G2\/p97 is commonly interpreted in the context of developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans adherens junction, axon, and cytosol, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between adherens junction, axon, and cytosol across matched conditions\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for eIF4G2\/p97. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in eIF4G2\/p97 reflect biology rather than handling. When interpreting eIF4G2\/p97, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep eIF4G2\/p97 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577739223385,"sku":"F1432-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577739256153,"sku":"F1432-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577739288921,"sku":"F1432-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1432-IF.png?v=1773599744","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/eif4g2-p97-antibody-sc-f1432","provider":"Absource Diagnostics","version":"1.0","type":"link"}