{"product_id":"ednra-antibody-sc-f3195","title":"Endothelin A Receptor\/ET-A Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eEndothelin A Receptor\/ET-A is a class A G-protein-coupled receptor (GPCR) encoded by the EDNRA gene on chromosome 4q31. 2, primarily mediating vasoconstriction, cell proliferation, and extracellular matrix accumulation in response to endothelin-1 (ET-1) binding. Structurally, ET-A features seven transmembrane helices, with an extracellular domain forming a high-affinity binding pocket for ET-1, triggering G-protein activation and downstream signaling through pathways like phospholipase C (PLC), phospholipase D (PLD), and MAPK. Depending on the literature source, EDNRA may also be discussed as Endothelin A Receptor\/ET-A.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following EDNRA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eEDNRA is commonly interpreted in the context of cardiovascular and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for EDNRA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in EDNRA reflect biology rather than handling. When interpreting EDNRA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep EDNRA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578007757145,"sku":"F3195-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578007789913,"sku":"F3195-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578007822681,"sku":"F3195-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3195-wb.gif?v=1773601002","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ednra-antibody-sc-f3195","provider":"Absource Diagnostics","version":"1.0","type":"link"}