{"product_id":"drp1-antibody-sc-f2888","title":"DRP1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eDynamin-related protein 1 (Drp1) is a GTPase from the dynamin superfamily, essential for mitochondrial fission. Unlike classic dynamins, Drp1 lacks a pleckstrin homology motif and proline-rich tail but retains a GTPase domain, middle domain, variable domain, and a C-terminal GTPase effector domain (GED). Drp1 is ubiquitously expressed across tissues, with higher levels in the heart, brain, skeletal muscle, kidney, and testis, and is influenced by factors like stress, nutrient availability, and hormones. Depending on the literature source, DRP1 may also be discussed as DLP1 and DNM1L.\u003c\/p\u003e\u003cp\u003eReported cellular context includes coated pit, cytoplasm, cytoplasmic vesicle, and golgi apparatus, which can matter when signal is compared across treatments or changing cell states. Following DRP1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eDRP1 is commonly interpreted in the context of neuroscience, cardiovascular, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans coated pit, cytoplasm, and cytoplasmic vesicle, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between coated pit, cytoplasm, and cytoplasmic vesicle across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for DRP1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in DRP1 reflect biology rather than handling. When interpreting DRP1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep DRP1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577983050073,"sku":"F2888-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577983082841,"sku":"F2888-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577983115609,"sku":"F2888-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2888-IF.png?v=1773600784","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/drp1-antibody-sc-f2888","provider":"Absource Diagnostics","version":"1.0","type":"link"}