{"product_id":"dmh1-s7146","title":"DMH1","description":"\u003cp\u003e\u003cstrong\u003eDMH1\u003c\/strong\u003e is an inhibitor of TGF-beta \/ Smad used in studies of PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs. It is especially relevant in autophagy, cancer, and cell signaling models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting TGF-beta \/ Smad, DMH1 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TGF-beta \/ Smad\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, DMH1 is appropriate when a defined chemical perturbant is needed to connect TGF-beta \/ Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809458266457,"sku":"S7146-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809458299225,"sku":"S7146-50MG","price":446.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809458331993,"sku":"S7146-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809458364761,"sku":"S7146-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/DMH1-chemical-structure-s7146.gif?v=1776200992","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/dmh1-s7146","provider":"Absource Diagnostics","version":"1.0","type":"link"}