{"product_id":"dimethyl-itaconate-e1281","title":"Dimethyl itaconate","description":"\u003cp\u003e\u003cstrong\u003eDimethyl itaconate\u003c\/strong\u003e is a modulator of NLRP3 and NRF2 used in studies of NF-kB Signaling and Immune Signaling and related signaling programs. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in immunology, inflammation, and oxidative stress models.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating NLRP3 and NRF2, Dimethyl itaconate can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology, inflammation, and oxidative stress models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving NLRP3 and NRF2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Dimethyl itaconate is appropriate when a defined chemical perturbant is needed to connect NLRP3 and NRF2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology, inflammation, and oxidative stress models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"100 mg","offer_id":57804373000537,"sku":"E1281-100MG","price":68.0,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":57804373033305,"sku":"E1281-250MG","price":136.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e1281-dimethyl-itaconate-chemical-structure.gif?v=1776166742","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/dimethyl-itaconate-e1281","provider":"Absource Diagnostics","version":"1.0","type":"link"}