{"product_id":"d-4476-s7642","title":"D 4476","description":"\u003cp\u003e\u003cstrong\u003eD 4476\u003c\/strong\u003e is an inhibitor of CK2 used in studies of kinase signaling. In practice, this places the compound in experiments that measure phosphorylation signaling, target engagement, and selectivity relationships in cancer, cell signaling, and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting CK2, D 4476 can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cell signaling, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CK2\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer, cell signaling, and metabolism models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, D 4476 is appropriate when a defined chemical perturbant is needed to connect CK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809526260057,"sku":"S7642-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809526292825,"sku":"S7642-50MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57809526325593,"sku":"S7642-200MG","price":940.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809526358361,"sku":"S7642-1G","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809526391129,"sku":"S7642-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/d-4476-chemcial-structure-s7642.gif?v=1776201654","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/d-4476-s7642","provider":"Absource Diagnostics","version":"1.0","type":"link"}