{"product_id":"ctsb-antibody-sc-f3378","title":"Cathepsin B Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCTSB is a target of interest in many antibody-based workflows. Cathepsin B is a lysosomal cysteine protease belonging to the papain family. It is initially synthesized as a 339-amino acid preproenzyme, which contains a 17-residue signal peptide. This precursor undergoes processing to form a mature enzyme of 30 kDa, consisting of a 25-26 kDa heavy chain and a 5 kDa light chain linked by disulfide bonds. Depending on the literature source, CTSB may also be discussed as Cathepsin B and G60.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, lysosome, membrane, and secreted, which can matter when signal is compared across treatments or changing cell states. Following CTSB across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCTSB is commonly interpreted in the context of cancer and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, lysosome, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, lysosome, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CTSB. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CTSB reflect biology rather than handling. When interpreting CTSB, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CTSB trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578019094873,"sku":"F3378-20UL","price":179.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578019127641,"sku":"F3378-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578019160409,"sku":"F3378-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3378-IF.png?v=1773601173","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ctsb-antibody-sc-f3378","provider":"Absource Diagnostics","version":"1.0","type":"link"}