{"product_id":"ctnnb1-antibody-sc-f0494","title":"Phospho-β-Catenin (Ser552) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCTNNB1 is a target of interest in many antibody-based workflows. β-Catenin is essential for both cell adhesion and transcriptional regulation within the Wnt signalling pathway, significantly influencing tumor progression and metastasis in non-small cell lung cancer (NSCLC). When β-catenin is not phosphorylated, it is targeted for degradation; however, phosphorylation at sites like Ser552 increases its stability, enabling its movement to the nucleus and activation of genes responsible for epithelial-mesenchymal transition (EMT) and invasion. Depending on the literature source, CTNNB1 may also be discussed as Phospho-beta-Catenin (Ser552).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cell membrane, cell projection, and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following CTNNB1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCTNNB1 is commonly interpreted in the context of cancer and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cell membrane, and cell projection, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cell membrane, and cell projection across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CTNNB1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CTNNB1 reflect biology rather than handling. When interpreting CTNNB1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CTNNB1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577464398169,"sku":"F0494-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577464430937,"sku":"F0494-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577464463705,"sku":"F0494-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0494-wb.gif?v=1773598538","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ctnnb1-antibody-sc-f0494","provider":"Absource Diagnostics","version":"1.0","type":"link"}