{"product_id":"crkl-antibody-sc-f3775","title":"CrkL Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCrk-like protein (CRKL) is an adaptor protein from the Crk family, composed of a single polypeptide chain containing one N-terminal Src homology 2 (SH2) domain and two tandem Src homology 3 (SH3) domains, SH3n (N-terminal) and SH3c (C-terminal). The SH2 domain binds phosphotyrosine motifs on tyrosine kinase substrates such as BCAR1, receptor tyrosine kinases like PDGFRA, and scaffolding proteins including GAB and DOK1. Depending on the literature source, CRKL may also be discussed as Crk-like protein.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and cytosol, which can matter when signal is compared across treatments or changing cell states. Following CRKL across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCRKL is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and cytosol, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and cytosol across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CRKL. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CRKL reflect biology rather than handling. When interpreting CRKL, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CRKL trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578046161241,"sku":"F3775-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578046194009,"sku":"F3775-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578046226777,"sku":"F3775-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3775-IF.png?v=1773601472","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/crkl-antibody-sc-f3775","provider":"Absource Diagnostics","version":"1.0","type":"link"}