{"product_id":"cilofexor-gs-9674-s6547","title":"Cilofexor (GS-9674)","description":"\u003cp\u003e\u003cstrong\u003eCilofexor (GS-9674)\u003c\/strong\u003e is an agonist of FXR used in studies of Hormone Signaling and Metabolic Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to ligand-dependent transcriptional programs and endocrine regulation and metabolic regulation, energy sensing, and enzyme-linked homeostasis in endocrinology and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating FXR, Cilofexor (GS-9674) can be used to examine ligand-dependent transcriptional programs and endocrine regulation and metabolic regulation, energy sensing, and enzyme-linked homeostasis. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In endocrinology and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving FXR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Hormone Signaling and Metabolic Signaling\u003c\/li\u003e\n\u003cli\u003eAgonist-response and downstream signaling studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Cilofexor (GS-9674) is appropriate when a defined chemical perturbant is needed to connect FXR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in endocrinology and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809394598233,"sku":"S6547-5MG","price":154.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809394631001,"sku":"S6547-25MG","price":488.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/cilofexor-gs-9674-chemical-structure-s6547.gif?v=1776200070","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/cilofexor-gs-9674-s6547","provider":"Absource Diagnostics","version":"1.0","type":"link"}