{"product_id":"cdc2-antibody-sc-f3185","title":"Phospho-CDK1 (T161) + CDK2\/3 (T160) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCDC2 is a target of interest in many antibody-based workflows. Phospho-CDK1 (Thr 161) + CDK2\/CDK3 (Thr 160) are closely related serine\/threonine kinases that orchestrate key transitions in the cell cycle, with CDK1 driving the G2\/M transition and CDK2\/CDK3 primarily regulating the G1\/S and G0-G1 transitions. Structurally, they share a conserved kinase domain featuring a regulatory activation loop that must be phosphorylated-Thr161 in CDK1 and Thr160 in CDK2\/CDK3-for full activation. Depending on the literature source, CDC2 may also be discussed as Phospho-CDK1 (T161) + CDK2\/3 (T160) and CDC28A.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoskeleton, mitochondrion, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following CDC2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCDC2 is commonly interpreted in the context of cell cycle and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and mitochondrion, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoskeleton, and mitochondrion across matched conditions\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CDC2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CDC2 reflect biology rather than handling. When interpreting CDC2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CDC2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578006937945,"sku":"F3185-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578006970713,"sku":"F3185-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578007003481,"sku":"F3185-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3185-IF.png?v=1773600986","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/cdc2-antibody-sc-f3185","provider":"Absource Diagnostics","version":"1.0","type":"link"}