{"product_id":"cd321-antibody-sc-f2029","title":"Junctional Adhesion Molecule 1\/JAM-A Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCD321 is a target of interest in many antibody-based workflows. Junctional adhesion molecule A (JAM-A), also known as JAM-1, is a transmembrane protein belonging to the immunoglobulin superfamily that plays a key role in regulating tight junctions. It is specifically located at the tight junctions of epithelial and endothelial cells, where it contributes to the maintenance of junctional integrity and permeability. Depending on the literature source, CD321 may also be discussed as Junctional Adhesion Molecule 1\/JAM-A and F11R.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cell membrane, membrane, and tight junction, which can matter when signal is compared across treatments or changing cell states. Following CD321 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCD321 is commonly interpreted in the context of immunology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cell membrane, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cell membrane, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD321. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD321 reflect biology rather than handling. When interpreting CD321, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CD321 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577846407513,"sku":"F2029-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577846440281,"sku":"F2029-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577846473049,"sku":"F2029-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2029-IF.png?v=1773600121","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/cd321-antibody-sc-f2029","provider":"Absource Diagnostics","version":"1.0","type":"link"}