{"product_id":"cd-mpr-antibody-sc-f2833","title":"M6PR (cation dependent) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eM6PR (cation dependent) is also called cation-dependent mannose 6-phosphate receptor (CD-MPR) is a type I transmembrane glycoprotein and a member of the P-type lectin family that plays a central role in lysosomal enzyme trafficking. Structurally, it functions as a homodimer, with each subunit containing a single mannose 6-phosphate (Man-6-P) binding site in its extracytoplasmic domain (residues 1-154), and its binding affinity is modulated by pH and divalent cations. Depending on the literature source, CD-MPR may also be discussed as M6PR (cation dependent) and MPR46.\u003c\/p\u003e\u003cp\u003eReported cellular context includes lysosome and membrane, which can matter when signal is compared across treatments or changing cell states. Following CD-MPR across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCD-MPR is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans lysosome and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between lysosome and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD-MPR. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD-MPR reflect biology rather than handling. When interpreting CD-MPR, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CD-MPR trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577974727001,"sku":"F2833-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577974759769,"sku":"F2833-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577974792537,"sku":"F2833-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2833-IF.png?v=1773600733","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/cd-mpr-antibody-sc-f2833","provider":"Absource Diagnostics","version":"1.0","type":"link"}