{"product_id":"ccnd1-antibody-sc-f0137","title":"Cyclin D1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCyclin D1 is a 36-kDa protein encoded by the CCND1 gene on chromosome 11q13. It plays a crucial role in regulating the cell cycle, particularly in promoting the transition from G1 to S phase. Cyclin D1 forms a complex with CDK4\/6, which phosphorylates retinoblastoma (RB) protein, releasing E2F transcription factors to drive cell proliferation. Depending on the literature source, CCND1 may also be discussed as Cyclin D1 and Cyclin D.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, membrane, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following CCND1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCCND1 is commonly interpreted in the context of cancer and cell cycle research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, membrane, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, membrane, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CCND1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CCND1 reflect biology rather than handling. When interpreting CCND1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CCND1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577384640857,"sku":"F0137-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577384673625,"sku":"F0137-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577384706393,"sku":"F0137-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0137-IF.png?v=1773598137","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ccnd1-antibody-sc-f0137","provider":"Absource Diagnostics","version":"1.0","type":"link"}