{"product_id":"bexotegrast-pln-74809-e1385","title":"Bexotegrast (PLN-74809)","description":"\u003cp\u003e\u003cstrong\u003eBexotegrast (PLN-74809)\u003c\/strong\u003e is an inhibitor of Integrins used in studies of TGF-beta \/ Smad Signaling. It is especially relevant in angiogenesis, cancer, and developmental biology models, where defined compound exposure can be linked to Smad-mediated transcription, differentiation, and fibrotic signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Integrins, Bexotegrast (PLN-74809) can be used to examine Smad-mediated transcription, differentiation, and fibrotic signaling. This context is compatible with TGF-beta\/Smad reporter and transcriptional assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In angiogenesis, cancer, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Integrins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to TGF-beta \/ Smad Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in angiogenesis, cancer, and developmental biology models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Bexotegrast (PLN-74809) is appropriate when a defined chemical perturbant is needed to connect Integrins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804390170969,"sku":"E1385-5MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804390203737,"sku":"E1385-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804390236505,"sku":"E1385-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57804390269273,"sku":"E1385-1G","price":2918.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e1385-Bexotegrast-chemical-structure.png?v=1776166851","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/bexotegrast-pln-74809-e1385","provider":"Absource Diagnostics","version":"1.0","type":"link"}