{"product_id":"axl-antibody-sc-f0178","title":"Axl Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAXL, a member of the TAM family of receptor tyrosine kinases (RTKs) along with TYRO3 and MER, plays a crucial role in tumor progression and metastasis, with its expression linked to poor survival in various cancers. GAS6 binds all TAM receptors, favoring AXL, while protein S binds only MER and TYRO3.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following AXL across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAXL is commonly interpreted in the context of cancer and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for AXL. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in AXL reflect biology rather than handling. When interpreting AXL, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep AXL trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577423700313,"sku":"F0178-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577423733081,"sku":"F0178-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577423765849,"sku":"F0178-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0178-IF.png?v=1773598184","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/axl-antibody-sc-f0178","provider":"Absource Diagnostics","version":"1.0","type":"link"}