{"product_id":"app-antibody-sc-f2535","title":"Amyloid Precursor Protein Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAmyloid Precursor Protein (APP) is a type I transmembrane glycoprotein primarily expressed in the brain, concentrated at neuronal synapses, and involved in critical cellular functions, including synaptogenesis, neuronal growth, synaptic plasticity, and survival. APP consists of a large extracellular N-terminal domain with subdomains like the growth factor-like domain (GFLD) and copper-binding domain (CuBD), a single transmembrane α-helix, and a short intracellular C-terminal domain containing conserved motifs such as YENPTY for intracellular signalling and trafficking. Depending on the literature source, APP may also be discussed as Amyloid Precursor Protein and C-Terminal.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, coated pit, and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following APP across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAPP is commonly interpreted in the context of neuroscience research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and coated pit, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and coated pit across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for APP. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in APP reflect biology rather than handling. When interpreting APP, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep APP trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577958768985,"sku":"F2535-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577958801753,"sku":"F2535-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577958834521,"sku":"F2535-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2535-IF.png?v=1773600518","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/app-antibody-sc-f2535","provider":"Absource Diagnostics","version":"1.0","type":"link"}