{"product_id":"amitriptyline-hcl-s3183","title":"Amitriptyline HCl","description":"\u003cp\u003e\u003cstrong\u003eAmitriptyline HCl\u003c\/strong\u003e is an inhibitor of Serotonin Transporter used in studies of GPCR Signaling and Neurotransmission. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability in neuroscience models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Serotonin Transporter, Amitriptyline HCl can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability. The transporter annotation adds relevance to transport, uptake\/efflux, and permeability assays, together with downstream-response mapping in the same experimental setting. In neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Serotonin Transporter\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling and Neurotransmission\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eTransport, uptake\/efflux, and permeability assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Amitriptyline HCl is appropriate when a defined chemical perturbant is needed to connect Serotonin Transporter with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"50 mg","offer_id":57808758538585,"sku":"S3183-50MG","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57808758571353,"sku":"S3183-1G","price":658.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Amitriptyline-hydrochloride-chemical-structure-s3183.gif?v=1776194597","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/amitriptyline-hcl-s3183","provider":"Absource Diagnostics","version":"1.0","type":"link"}