{"product_id":"alvespimycin-17-dmag-hydrochloride-s1142","title":"Alvespimycin (17-DMAG)Hydrochloride","description":"\u003cp\u003e\u003cstrong\u003eAlvespimycin (17-DMAG)Hydrochloride\u003c\/strong\u003e is an inhibitor of HSP90 used in studies of target-focused biology. In practice, this places the compound in experiments that measure annotated target biology and downstream cellular responses in cancer and protein homeostasis models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HSP90, Alvespimycin (17-DMAG)Hydrochloride can be used to examine annotated target biology and downstream cellular responses. That positioning is consistent with concentration-response inhibition and target-dependence studies and with follow-up studies that compare concentration-dependent responses across orthogonal assay formats. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HSP90\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer and protein homeostasis models\u003c\/li\u003e\n\u003cli\u003eCombination studies with orthogonal perturbagens\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Alvespimycin (17-DMAG)Hydrochloride is appropriate when a defined chemical perturbant is needed to connect HSP90 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805230276953,"sku":"S1142-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805230309721,"sku":"S1142-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805230342489,"sku":"S1142-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/17-DMAG-Alvespimycin-chemical-structure-S1142.gif?v=1776172976","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/alvespimycin-17-dmag-hydrochloride-s1142","provider":"Absource Diagnostics","version":"1.0","type":"link"}